Salvage Therapy is a final treatment for people who are non-responsive to or cannot tolerate other available therapies for a particular condition, such as HIV infection or AIDS. Those people who are in the category "salvage therapy" have a prognosis that is often very poor based on the advanced stage of their illness.

Salvage Therapy is given in the hope of a cure or in the hope of providing the patient with more quality time or a better quality existence.

In oncology, the term refers to treatments given after a tumor has not responded to other treatments, or any treatment given after recurrence of a tumor.